ARBs Explained: What They Are, How They Work, and Which Ones Doctors Recommend

When your blood pressure stays too high, your body’s natural systems can go into overdrive. One of those systems involves a hormone called angiotensin II, a powerful chemical that narrows blood vessels and raises blood pressure. ARBs, or angiotensin receptor blockers, angiotensin II receptor antagonists are a class of medications designed to stop this hormone from doing its job. Unlike ACE inhibitors that block the creation of angiotensin II, ARBs simply block its receptors—like putting a lock on the door so the hormone can’t get in. This keeps your blood vessels relaxed, lowers pressure, and reduces strain on your heart and kidneys.

Doctors often choose ARBs for patients who can’t tolerate ACE inhibitors because of a persistent cough—a common side effect. They’re also preferred for people with diabetes and kidney disease, since ARBs like losartan, a widely prescribed ARB that helps protect kidney function and valsartan, another common ARB used after heart attacks have been shown to slow kidney damage. ARBs don’t just lower numbers—they help prevent long-term damage. Studies show they reduce hospital stays for heart failure and cut the risk of stroke in high-risk patients. They’re not a one-size-fits-all solution, though. Some people respond better to ARBs than others, and side effects like dizziness or high potassium levels can happen. That’s why doctors often start low and go slow, especially in older adults or those with kidney issues.

What you’ll find in this collection isn’t just a list of ARB names. It’s real-world insight into how these drugs fit into daily life. You’ll read about how ARBs compare to other blood pressure meds like spironolactone and eplerenone, why some patients switch between them, and how they interact with other common drugs. You’ll also see how ARBs fit into broader treatment plans—for heart failure, diabetes, and even conditions like preeclampsia. These aren’t textbook summaries. They’re stories from people managing their health, backed by what actually works in clinics and homes.